The Sanders Lab aims to identify the etiology of developmental disorders through the discovery of genetic risk factors. Over the past few years there has been rapid progress in identifying the genes that play a role in autism spectrum disorder (ASD). We aim to continue this progress, leverage these findings to build a more complete understanding of ASD, and to extend this approach to other human disorders, including congenital malformations.
There are five main areas of research:
The Sanders Lab is primarily a bioinformatic group that uses a wide range of genomic, bioinformatic, and statistical methods including: whole-exome sequencing, whole-genome sequencing, de novo mutation detection, RNA-Seq, and ChIP-Seq.
We work with closely with numerous collaborators, including the State Lab and Bender Lab at UCSF, the Devlin Lab at UPMC, the Roeder Lab at Carnegie Mellon, the Sestan Lab, and the Talkowski lab at Harvard.
If you are interested in joining please go to the recruitment page.
We are grateful for funding from the National Institute of Mental Health and the The Simons Foundation Autism Research Initiative, the Autism Science Foundation, and the Brain & Behavior Research Foundation.
New paper! Young et al. 2021 published in eLife on 3D atlas construction, applied to the Allen Developing Mouse Brain Atlas.Sept 27 2020
New paper! An et al. 2018 published in Science, highlights the role of promoters in autism.Dec 1st 2018
Our work with the Autism Sequencing Consortium identifies 99 autism genes, paper submitted to BioRxiv .May 29th 2018
Donna presents the lab’s recent work, 'Analytical Framework for WGS and its Implications for ASD' at the PGC Statistical Genetics Group online meeting.May 9th 2018
Stephan, Donna, Brooke and Joon travel to Rotterdam, Netherlands, to share our latest work at INSAR 2018.May 7th 2018
Donna and Joon’s latest works highlighted in Autism Science Foundation Podcast.April 27th 2018
New paper! Werling et al. 2018 published in Nature Genetics in collaboration with the Autism Sequencing Consortium.April 12th 2017
Stephan with Kevin Bender (UCSF) talk about 'The genetics and physiology of SCN2A in autism and early-onset seizures' at the Simons VIP Connect.